Paracetamol blocks cyclooxygenase I and II only in the central nervous system, affecting the pain and thermoregulatory centers (in inflamed tissues cellular peroxidase neutralize the effect of paracetamol on cyclooxygenase), which explains the almost complete absence of anti-inflammatory effect. No effect on prostaglandin synthesis in peripheral tissues causes lack of a testosterone propionate vs enanthate negative effect on water-salt exchange (sodium and water retention), and gastrointestinal mucosa.The possibility of formation metgemoglobina- unlikely.
Indications . Moderately or weakly expressed pain (headache, toothache, migraine pain, neuralgia, myalgia) Increased body temperature in cold and other infectious and inflammatory diseases.
- Hypersensitivity to paracetamol.
- Children under 15 years old.
Be wary – kidney and liver failure, benign hyperbilirubinemia (including Gilbert’s syndrome, viral hepatitis, alcoholic liver disease), alcoholism, pregnancy, lactation, old age, lack of glucose-6-phosphate dehydrogenase.
Dosage and administration:
Administered orally with plenty of fluids 1-2 tablets 2-3 times a day at intervals of at least 4 hours. The maximum single dose for adults and children over 15 years is 2 tablets (1000 mg) daily – 8 tablets (4000 mg).
In patients with impaired liver testosterone propionate vs enanthate and kidney function, with Gilbert’s syndrome and in elderly patients with an interval between doses of the drug should be at least 8 hours and the daily dose should be reduced.
The duration of the maximum of 5 days when administered as an analgesic and 3 days as an antipyretic.
- Nausea, vomiting, epigastric pain, allergic reactions (skin rash, pruritus, urticaria, angioedema).
- Rarely – anemia, leukopenia, grombotsitopeniya, agranulocytosis.
- With prolonged use at high doses – gepatotoksicheekoe effects, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia.
- Renal toxicity (renal colic, Piura, interstitial nephritis, papillary necrosis).
Symptoms: pale skin, anorexia, nausea, vomiting; gepatonekroz (necrosis severity is directly dependent on the degree of overdose). The toxic effect of the drug in adults is possible after receiving more than 10-15 g of paracetamol: increased activity of “liver” transaminases, increased prothrombin time, detailed clinical picture of liver damage manifests itself in 1-6 days. Rarely hepatic dysfunction develops lightning speed and can be complicated by renal insufficiency (tubular necrosis).
Treatment: stop taking the drug, gastric lavage, activated charcoal to take. Further therapeutic measures should be undertaken in a hospital: the introduction of donators of and precursors of glutathione synthesis – through methionine 8-9 h after the overdose . The need for additional therapeutic measures is determined depending on the concentration of paracetamol in the blood, and the time elapsed after administration.
Interaction: Stimulants microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which makes the possibility of severe intoxication with small overdoses. Ethanol contributes to the development of acute pancreatitis. Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxicity.
Reduces the effectiveness of uricosuric drugs.
With caution and under medical supervision should testosterone propionate vs enanthate use the drug to patients with impaired hepatic or renal function, in conjunction with other anti-inflammatory and analgesic agents, as well as with anticoagulants and drugs that affect the central nervous system. When receiving metoclopramide, domperidone or cholestyramine also need to consult with your doctor.
Distorts the performance of laboratory tests cypionate vs enanthate for the quantitative determination of uric acid in the plasma.
In order to prevent liver toxicity of paracetamol should not be combined with alcohol intake, and take people prone to chronic alcohol consumption. The risk of liver damage increases in patients with alcoholic hepatosis.
Prolonged use of the drug is necessary to monitor patterns of peripheral blood and functional state of the liver. Running low dose t3 clen cycle trying to lose bodyfat isn’t a real hot idea imo.