Agents affecting gastric acidity. Drugs that increase the testosterone propionate dosage of gastric juice (hydrochloride magnesium / aluminum hydroxide, omeprazole) do not affect the biological digestibility of Atomoxetine.
Agents acting on the secretion of norepinephrine. Agents acting on the secretion of norepinephrine should be administered with caution with atomoxetine because of the potential gain or synergistic pharmacological effects.
Drugs with high affinity to plasma proteins. Atomoxetine has no effect on the binding of warfarin, acetylsalicylic acid, phenytoin and the diazepam to human albumin.
Drugs with a known effect of lowering the threshold for seizure activity
(Antidepressants, neuroleptics, mefloquine, tramadol). Caution must be exercised with concomitant administration.
Symptoms as impaired attention and hyperactivity (identified in more than one social environment, such as at home and at school) can manifest as a concentration deficiency, distractibility, excessive restlessness, impulsiveness, disorganization, restlessness, and other similar conduct disorders diagnosis should meet the criteria .
Suicidal ideation and behavior. On the background of the drug in clinical trials in children and adolescents increases the risk of suicidal thoughts. In the course of 12 clinical studies in 2200 patients (including 1357 patients treated with atomoxetine and 851 patients receiving placebo), one group Atomoxetine in 0.37% of cases were identified the development of suicidal thoughts (5 out of 1357 patients) in the placebo group, suicidal thoughts were not identified. During these clinical studies reported a suicide attempt, suicide was not completed.
Allergic reactions. In rare cases, patients taking atomoxetine, marked allergic reactions such as rash, angioedema, urticaria.
.Atomoxetine should not be used for at least 2 weeks after discontinuation of treatment should not begin within 2 weeks after discontinuation of atomoxetine. The cardiovascular system. Many patients taking atomoxetine, there was a slight increase in pulse . In most cases, these changes testosterone propionate dosage were not clinically significant effect. Atomoxetine should be used with caution in patients with hypertension, tachycardia, with cardiovascular disease or cerebrovascular. Cases of orthostatic hypotension are also marked. Used with caution in conditions that may lead to hypotension. Use with caution in patients with hereditary or congenital
Against the background of the use of stimulants, registered for the treatment of children with rough heart disease, in violation of its structure was identified an increased risk of sudden cardiac death. Atomoxetine does not belong to the class of stimulants, because it has an alternative mechanism of therapeutic action in the treatment of testosterone propionate dosage. However, given the total registered indications for use , caution should be exercised when using atomoxetine in patients with: severe physical congestion, while taking psychostimulants, family history of sudden cardiac death. Atomoxetine should not be used in patients with heart disease rough.
Violation of the liver or kidney. It was reported about rare cases of serious liver injury in patients receiving atomoxetine (described two cases of pronounced increase in liver enzymes and bilirubin 2 million patients). Patients with symptoms of jaundice or laboratory parameters identified which indicate liver dysfunction, treatment with atomoxetine should be abolished. hotbol