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testosterone cypionate vs propionate

in the complex therapy of chronic heart failure II (in the presence of clinical manifestations), III and IV functional class; tachysystolic form of flicker and flutter and paroxysmal chronic course (especially when combined with chronic heart failure).

Contraindications:
Hypersensitivity to the drug, glycoside intoxication, testosterone cypionate vs propionate syndrome, atrioventricular block II degree, intermittent complete blockade.

Precautions (comparing the benefit / risk): atrioventricular block I degree, sick sinus syndrome without pacemaker, the probability of unstable conduct on the atrioventricular node, specifying a history of attacks of Morgagni-Adams-Stokes, hypertrophic subaortic stenosis, isolated mitral stenosis with a rare frequency heart rate, cardiac asthma in patients with mitral stenosis (in the absence of the one-hisistolicheskoy atrial fibrillation), acute myocardial infarction, unstable angina, arteriovenous shunt, hypoxia, heart failure with diastolic dysfunction (restrictive cardiomyopathy, amyloidosis heart, constrictive pericarditis, tamponade heart), arrythmia, marked dilatation of the heart cavities, “pulmonary” heart.
Electrolyte disorders: hypokalemia, hypomagnesemia, hypercalcemia, hypernatremia. Hypothyroidism, alkalosis, myocarditis, advanced age, renal hepatic insufficiency, obesity.

Dosage and administration
by slow intravenous injection. Dose selected testosterone cypionate vs propionate individually depending on the nosology and patient response to therapy. The maximum single dose Р0.25 mg daily mg -1. The drug is administered in low doses of 0.1-015 mg at intervals of from 30 minutes to 2 hours. At an average rate digitaliza-tion in the saturation period is usually 0.25 mg administered two times a day at intervals of 12 hours. The period saturation averages 2 days. Maintenance dose strofantinom-G does not exceed 0.25 mg / day.

Side effects:
Occasionally allergic reactions. Other side effects are mainly due to drug overdose or increased sensitivity to the patient’s cardiac glycosides.

Overdose
Symptoms of overdose strofantinom-T varied. Cardio-vascular system: arrhythmia, including bradycardia, AV-block, ventricular tachycardia or extrasystole, ventricular fibrillation.
On the part of the digestive tract: anorexia, nausea, vomiting, diarrhea.
On the part of the central nervous system and sensory organs: headache , fatigue. dizziness, rarely – staining the surrounding objects in green and yellow colors, a sense of flicker flies before his eyes, blurred vision, scotoma, macro- and micropsia: very rarely confusion, sinkoialnye state. With the development of glycoside intoxication drug should be discontinued; assign the patient potassium supplements, parenteral administration unitiola, symptomatic therapy.

Interaction with other drugs
agonists, methylxanthines, reserpine, tricyclic antidepressants increases the risk of heart rhythm disorders.
Beta-blockers, and antiarrhythmics  class, verapamil and magnesium sulfate increase the severity of reducing the conductivity .
Quinidine, methyldopa, clonidine, spironolactone, amiodarone, verapamil , captopril, erythromycin and tetracycline increase the concentration in the blood (competitive decreased secretion of the proximal renal tubules).
Corticosteroids and diuretics increase the risk of hypokalemia and hypomagnesemia, angiotensin-converting enzyme  inhibitors and angiotensin receptor Рreduce.
calcium salts, catecholamines, diuretics ( more kartoangidrazy thiazide and inhibitors), glucocorticosteroids, insulin, increase the risk of glycoside intoxication.

Cautions
With extreme caution in patients with hyperthyroidism and atrial premature beats.
In view of the low therapeutic range during treatment requires careful medical monitoring and individual dose selection.
In case of violation of renal excretory function should be reduced dose (prevention glycoside intoxication).
Overdose probability increases with hypokalemia , hypomagnesemia, hypercalcemia, hypernatremia, marked dilatation of the heart cavities, “pulmonary” heart, alkalosis, in elderly patients. Particular caution and testosterone cypionate vs propionatemonitoring is required in case of violation of the conduction AV.

Product form
solution for intravenous administration of 0.250 mg / ml.
Packing: 1 ml ampoules of 10 pieces nested together with instructions for use and a lancet ampoule in a pile of cardboard.